Psoriasis
Psoriasis is a chronic, immune-mediated skin condition driven by dysregulated T-cell signalling, keratinocyte hyperproliferation, barrier dysfunction, and systemic inflammation. Its expression—erythematous plaques, scaling, and thickening—reflects an interplay of cutaneous immune activation, microbial imbalance, and impaired epidermal renewal. These processes are reinforced by gut–skin axis disruption, oxidative stress, and loss of skin tolerance, resulting in recurrent cycles of inflammation and epidermal dysregulation.
AWvi approaches psoriasis through biological restoration rather than suppression. Each solution targets a distinct contributor—internal or external—to the immunometabolic loop underlying chronic plaque formation. Through the synergy of inside-out and outside-in mechanisms, this approach supports immune modulation, barrier reinforcement, and microbial balance, offering a clinically relevant complement to medical therapies or a maintenance strategy in non-severe forms.
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Targeted Mechanisms of Action
The Skin Biotic
CORE ESSENTIAL – Fundamental to restore or maintain physiological skin function
The Skin Biotic provides systemic support through modulation of the gut–skin axis, a central driver of inflammatory signalling in psoriatic disease. It combines three proprietary Lactobacillus strains, a prebiotic substrate, and bioavailable Retinol and D-Biotin to recalibrate immune activity and epithelial function.
Its primary actions include:
- Reduction of IL-17 and IL-23 mediated inflammatory signalling
- Support of regulatory T-cell pathways that counter psoriatic immune activation
- Promotion of ceramide synthesis and improved epidermal cohesion
- Enhancement of epithelial turnover through microbiome-derived metabolites
By addressing systemic inflammation and microbiome imbalance, The Skin Biotic contributes to reducing flare intensity, increasing skin resilience, and supporting long-term immunological tolerance.
The Active Cream
CORE ESSENTIAL – Fundamental to restore or maintain physiological skin function
The Active Cream supports the cutaneous barrier and modulates inflammation, two essential goals in psoriatic skin maintenance. Its biomimetic lipids, multi-molecular hyaluronic acid, and ectoin provide targeted restoration and protection.
Key mechanisms include:
- Reinforcement of the lipid matrix to prevent barrier breakdown and fissuring
- Modulation of inflammatory mediators contributing to plaque persistence
- Support of hydration and elasticity in hyperkeratotic or scaling areas
- Enhancement of microbial homeostasis to reduce secondary aggravating factors
The Active Cream is well suited for use between flare episodes, as an adjunct to medical treatment, or in mild-to-moderate phenotypes where barrier reinforcement and inflammation control are primary objectives.
The Gentle Cleanser
STRATEGIC SUPPORT – Strongly recommended to enhance outcomes or address key needs
The Gentle Cleanser respects the needs of psoriatic skin, which is often fragile, inflamed, and highly reactive. Its ectoin-based, surfactant-free formula, combined with biomimetic hyaluronic acid and active fruit waters, offers effective cleansing without stripping the barrier or disrupting microbial balance.
Key benefits include:
- Preservation of microbial ecology that helps downregulate inflammatory flares
- Prevention of cleansing-induced barrier damage and scaling
- Reduction of epidermal stress responses via ectoin’s osmoprotective effects
- Maintenance of hydration and improved skin comfort during active lesions
This formulation helps mitigate one of the most overlooked triggers of flare recurrence: improper or aggressive cleansing.
Before & Afters
